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Verapamil, diltiazem can lead to an exaggeration of the gas x and propranolol AV conduction and sinus node function particularly in patients with impaired ventricular function and/or SA or AV conduction abnormalities. This may result in severe hypotension andbradycardia.The mean Cmax and AUC of nifedipine are increased by 64% and 79% respectively, by co-administration of propranolol.

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