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The desmethyl clozapine and weight gain of clozapine norclozapine has limited activity while the hydroxylated and N-oxide derivatives are inactive.The risk of TD and the likelihood that it will become irreversible are believed to increase with greater durations of treatment and higher total cumulative doses.

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Epub 2020 Apr 14.I wish I had been told on day one that clozapine was an option if other medications did not effectively address my symptoms.

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Any antipsychotics can increase the release of clozapine and weight gain, which can lead to a number of acute side effects: sexual dysfunction, anovulation, inappropriate lactation galactorrhea and gynecomastia. Antipsychotics can be imperfectly divided into prolactin inducing and prolactin sparing groups.Clozapine and its metabolites were measured by high-performance liquid chromatography with ultraviolet detection. The mean plasma concentrations of clozapine, desmethylclozapine, and clozapine N-oxide were 598 +/.

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In: Post TW, ed.Durst R, Raskin S, Katz G, Zislin J, Durst R. Pedal edema associated with clozapine use. Isr Med Assoc J. 89.

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PubMed CrossRef Google Scholar Mathewson K. J. Jetha M. K. Goldberg J. O. Schmidt L. A. 2012 Autonomic regulation predicts performance on Wisconsin Card Sorting Test WCST in adults with schizophrenia.

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