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Diclofenac sodium in fixed combination with misoprostol is used orally for anti-inflammatory activity and analgesic effects in the symptomatic treatment of rheumatoid arthritis and osteoarthritis in patients at high risk of developing NSAIA-induced gastric or duodenal ulcers and in patients at high risk of developing complications from these ulcers. Diclofenac sodium 1% gel Voltaren gel is used topically for the symptomatic treatment of osteoarthritis-related joint pain.Leukopenia, thrombocytopenia, purpura, ecchymosis, eosinophilia, melena, and rectal bleeding have occurred occasionally in patients receiving diclofenac.

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