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Nifedipine
Clinical data
Trade namesAdalat, Procardia, others
AHFS/Drugs.comMonograph
MedlinePlusa684028
Pregnancy categoryC: (USA)
Routes of administrationby mouth, topical
ATC codeC08CA05 ( WHO )
Pharmacokinetic data
Bioavailability45-56%
Protein binding92-98%
MetabolismGastrointestinal, Liver
Elimination half-life2 hours
ExcretionKidneys: >50%, Biliary: 5-15%

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And the length of time you take the medicine depend on the medical problem for which you are using the medicine. http://johnhorse.com, Patients prescribed LEVITRA who are taking alpha-blockers should be started on the lowest recommended starting dose of LEVITRA [see DOSAGE AND ADMINISTRATION and DRUG INTERACTIONS.

Serotonin 5-HT could potentiate subsequent ACh- and ... The increased risk of myocardial infarction and death in patients nifedipine cream canada short-acting calcium-channel blocking agents may be associated with the arrhythmogenic, proischemic, negative inotropic, and/or prohemorrhagic effects of these agents; proischemic effects may result from reflex increases in sympathetic activity or from a reduction of coronary perfusion pressure induced by short-acting calcium-channel blocking agents.

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However, if discontinuation of nifedipine is necessary, sound clinical practice suggests that the dosage should be decreased gradually with close physician supervision.When pharmacologic therapy is indicated, a dihydro!

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In patients receiving nifedipine concomitantly nifedipine gel compound quinupristin and dalfopristin, blood pressure should be monitored and nifedipine dosage reduced if needed. Concomitant use of erythromycin an inhibitor of the CYP3A4 isoenzyme and nifedipine may nifedipine gel compound in inhibition of the metabolism of nifedipine and increased nifedipine exposure.Additional serious adverse effects including MI, congestive heart failure or pulmonary edema, and ventricular arrhythmia or conduction defects have reportedly occurred in 4% 2% and less than 0.

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Medline.Current ACOG guidelines for management of preterm labor state that there is no clear first-line tocolytic agent because of conflicting results regarding efficacy in comparative trials.

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A moderate decrease in platelet aggregation and increases in nifedipine lidocaine compound time, believed to be related to inhibition of calcium transport across the platelet membrane, have been nifedipine lidocaine compound in patients receiving nifedipine in a limited number of clinical studies; however, these findings were not considered to be clinically important.Although sirolimus is a substrate for the isoenzyme 3A4, o clinically important pharmacokinetic interactions were observed in patients receiving nifedipine a single 60-mg dose concomitantly with oral sirolimus a single 10-mg dose Although hydrodolasetron the main active metabolite of dolasetron is extensively metabolized, principally via the CYP system, including the 2D6 and 3A4 isoenzymes, concomitant use of IV or oral dolasetron with nifedipine did not alter the clearance of the metabolite.

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This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex updated 10 Aug 2020 Cerner Multum updated 3 Aug 2020 Wolters Kluwer updated 10 Aug 2020 andothers.In combination with delivery in a facility with a nifedipine cream canada III NICU, corticosteroids nifedipine cream canada improve outcomes of preterm birth.

Corticosteroids administered as late as 12 to 24 hours before preterm birth reduce the incidence of neonatal complications after preterm labor, including respiratory distress syndrome RDS intraventricular hemorrhage, and necrotizing enterocolitis.

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