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Dutasteride
Clinical data
Trade namesAvodart, others; Combodart, Duodart (with tamsulosin)
AHFS/Drugs.comMonograph
MedlinePlusa603001
Pregnancy categoryUS: X (Contraindicated) Not to be used during pregnancy
Routes of administrationBy mouth
Drug class5α-Reductase inhibitor
ATC codeG04CB02 ( WHO )
Legal status
Legal statusUK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability60% [1]
Protein binding99% [1]
MetabolismLiver (CYP3A4) [1]
Metabolites• 4'-Hydroxydutasteride [1] • 6'-Hydroxydutasteride [1] • 1,2-Dihydrodutasteride [1] (All three active) [1]
Elimination half-life4–5 weeks [2] [3]
ExcretionFeces: 40% (metabolites) [1] Urine: 5% (unchanged) [1]

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