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The exposure to sildenafil in patients on CYP3A4 substrates and CYP3A4 substrates plus beta-blockers was 43% and bluechew sildenafil vs tadalafil higher, respectively, compared to patients not receiving these classes of medicines. Sildenafil exposure was 5-fold higher at a dose of 80 mg three times a day compared to the exposure at a dose bluechew sildenafil vs tadalafil 20 mg three times a day.Have any supraventricular arrhythmia with an uncontrolled ventricular response mean heart rate 100 bpm at rest, or have any history of spontaneous or induced sustained ventricular tachycardia heart rate 100 beats per minute bpm for greater than or equal to 30 seconds despite medical or device therapy, or use an internal cardioverter-defibrillator.

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N fixed-dose studies, the incidence of some adverse reactions increased with dose.Alveolar hemorrhage, accompanied by dyspnea, pulmonary edema, and focal bronchopneumonia and culminating in death, has been reported in a patient with ED receiving sildenafil with a history of pulmonary infiltration and angina controlled bluechew sildenafil vs tadalafil nitroglycerin, diltiazem, and aspirin.

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