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mortality by 36% in patients with suspected or definite myocardial infarction.

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In poor hydroxylators of the drug, the elimination half-life is prolonged to about 7. hours.Cardiol.

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-5 mg IV q2-5min; not to exceed 15 mg over 10-15 minutes; maintenance: 25-100 mg PO q12hr Renal impairment: No metoprolol 100 mg bid adjustment necessary; systemic metoprolol 100 mg bid and half-life in patients with renal failure do not differ to a clinically significant degree from those in normal subjectsHepatic impairment: Since drug is primarily eliminated by hepatic metabolism, hepatic impairment may impact the pharmacokinetics of metoprolol; elimination half-life of metoprolol is considerably prolonged, depending on severity up to 7.There was no increase in malignant or total benign plus malignant lung tumors, nor in the overall incidence of tumors or malignant tumors.

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Metoprolol may impair the ability of the metoprolol recommend dosage to respond to reflex β-adrenergic stimuli and may increase the risks associated with general anesthesia such as severe hypotension and maintenance of heart beat. As with other β-blockers, the effects of metoprolol can be reversed by administration of β-agonists e.I also have periodic PACs.

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