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    Paracetamol acts as a reducing cosubstrate on the POX site and lessens availability of the ferryl protoporphyrin IX radical cation. This effect can be reduced in the presence of hydroperoxide-generating lipoxygenase enzymes within the cell peroxide tone or by swamping the POX site with substrate such as PG 2 Peroxide tone and swamping explain lack of peripheral analgesic effect, paracetamol for period pain dosage effect, and anti-inflammatory effect by paracetamol.Patients sensitive to aspirin may not be sensitive to acetaminophen; however, mild bronchospastic reactions with acetaminophen have been reported in some aspirin-sensitive asthmatics less than 5% of those tested Chronic toxicity studies in animals have shown that high doses of acetaminophen cause testicular atrophy and inhibition of spermatogenesis; the relevance of this finding to use in humans is not known.

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